Hematological and molecular characterization of beta-thalassemia/Hb Tak compound heterozygote.
نویسندگان
چکیده
We report a case of beta-thalassemia/Hb Tak compound heterozygote. The 7 year-old Thai boy presented with plethora since birth. Hemoglobin electrophoresis showed a major band between Hb A2 and Hb F and absent Hb A. DNA sequencing study demonstrated an AC insertion at the terminal codon of the beta-globin gene. The clinical feature of polycythemia reflected a high oxygen affinity of Hb Tak.
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ورودعنوان ژورنال:
- The Southeast Asian journal of tropical medicine and public health
دوره 34 2 شماره
صفحات -
تاریخ انتشار 2003